A new article published this month is presented by the University of Texas MD Anderson Cancer Center Department of Sarcoma Medical Oncology and is available to review on the Cancer Drug Resistance website: https://cdrjournal.com/article/view/4464. It is titled ‘Understanding Sarcoma Drug Resistance One Cell at a Time’ (January 20, 2022).
Briefly, this article discusses that the focus in GIST research is moving from the current focus on just histology, proteomics, and tumor genetics enabled by tumor samples, cell lines and mouse models which are limited in rare cancers like SDH-deficient GIST. The focus is evolving to include the longitudinal study of individual cells in the live tumor microenvironment which is enabled by the ability to isolate and characterize individual cells including non-tumor cells. This is a collection of massive amounts of temporal data using all the “-omics” and using major computational power using custom statistics and artificial intelligence to fully characterize the dynamics of tumor treatment resistance.
A pdf of the article is available here:
https://oaepublishstorage.blob.core.windows.net/a7ec4409-d3a1-4a5d-bbe4-9d5d84c9cdc1/4464.pdf
