Stivarga comes in 40 mg tablets. Once opened, it must be used within 28 days. Stivarga must be stored in the bottle that it comes in, the desiccant must remain in the bottle; keep bottle tightly sealed. Do not store in a daily or weekly pill box.
Many new cancer drugs are entering clinical practice and clinical trials. Many GIST patients are no longer responding to Gleevec or Sutent and thus are looking for clinical trials. Understanding strategies and grouping these new drugs into classes with other similar drugs may help patients understand some of their choices.
You may not have noticed, but the clinical trials section of the website has changed dramatically in the last month. This section of the website is now database-driven and has a lot more information.
Here is a presentation from Life Fest 2012 by LRG Science Director Jerry Call on the topic of Mutational & Plasma Testing.
The new treatment uses T cells, a type of immune cell that are taken from the patient’s body, genetically modified and then reinfused into the patient. These modified T cells are called chimeric antigen receptor (CAR) T cells. In previous trials with these modified T cells, tumor responses have been modest and they did not persist for long enough after being re-introduced into the patient. Using this second generation CAR T cell, Dr. Carl June and his colleagues at Penn obtained long-lasting persistence once the cells were re-introduced.
For many years, wild-type GIST tumors were a mystery. In 2007, Barbara Pasini, J. Aidan Carney, Constantine Stratakis and colleagues identified the first mutations in pediatric GIST tumors in a protein called succinate dehydrogenase (SDH). Coding (instructions) for making the SDH protein is contained in four subunits (genes), SDHA, SDHB, SHDC and SDHD. The group, led by Constantine Stratakis, initially reported mutations in three of the four subunits; SDHB, SHDC and SDHD. SHDA remained a mystery.
Pfizer Pharmaceuticals is offering Sutent in Touch, a program to support GIST patients on its drug Sutent. The program is free and patients can sign up by calling (1-877-578-8368). Sutent in Touch links patients to Oncology [...]
A new clinical trial combining targeted therapy with immunotherapy has just opened at Memorial Sloan-Kettering Cancer Center (MSKCC). This trial is the culmination of extensive pre-clinical investigations by MSKCC researchers. Although treatment with Gleevec [...]
A new gene panel takes mutation testing to a new level. The panel tests for mutations in 23 genes at once will help to properly classify wild-type GIST patients. Working with next generation sequencing [...]
Clinical Management of GIST Helsinki and Barcelona 2003-Conference Highlights Question: Your study is entitled “Differential Gene Expression Profiles of Imatinib-Sensitive and -Resistant Sarcoma Cell Lines After Exposure to Imatinib.” Could you briefly summarize your key [...]
