Mutations

/Mutations

New Blood Testing Technology May Be Effective in Detecting Mutations

A new blood testing technology may lead to major changes in treatment of Gastrointestinal Stromal Tumors. In a study presented in April by Dr. George Demetri of the Dana-Farber Cancer Institute at the American Association for Cancer Research annual meeting, the blood test was shown to be more effective than traditional biopsies in identifying secondary mutations in GIST.

By |2019-04-08T08:57:19-04:00June 11th, 2013|Mutational Testing, Mutations, News|

Understanding How GISTs Develop Enables Discovery of New Therapies

By Drs. Sebastian Bauer, West German Cancer Center, University of Essen, Germany and Jonathan Fletcher, Brigham & Women’s Hospital, Harvard University, LRG Research Team   Researchers talk plainly about microGISTs, how this cancer develops and what all [...]

By |2014-09-14T11:32:10-04:00January 23rd, 2013|Clinical Trials, Diagnosis, GIST Education, Mutations, News, Research|

New Treatments of D842V Mutations

 UPDATE - January 6th, 2011 by Jerry Call, LRG Science Coordinator The first ever clinical trial specifically for the PDGFRA D842V mutation has been announced by Arog pharmaceuticals. The phase II trial is scheduled [...]

By |2019-04-03T12:02:19-04:00January 6th, 2011|Clinical Trials, D842V, Diagnosis, Mutational Testing, Mutations, News, Research|

References – PDGFRA and D842V

1. Agaram NP, Besmer P, Wong GC, Guo T, Socci ND, Maki RG, DeSantis D, Brennan MF, Singer S, DeMatteo RP, Antonescu CR: Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors. Clin [...]

By |2014-09-03T13:23:03-04:00December 20th, 2007|D842V, Mutations, Research|

KIT and PDGFRA Mutations in GIST: A to Z

This is part one of a two-part series on “KIT and PDGFRA kinase mutations in GIST: from A to Z”. In this newsletter, Dr. Heinrich will provide a background on the role of kinase mutations in GIST, focusing largely on the biological and clinical implications of these mutations. In part two (which will be featured in the July 2007 edition of the newsletter, following the special “Five-year anniversary” edition),

Looking for Kinase Mutations in GISTs

This is the second of a two-part series on KIT and PDGFRA mutations in GISTs, written collaboratively by Drs. Michael Heinrich and Christopher Corless, LRG research team members. Please refer to the May issue of our newsletter for the first part titled, “KIT & PDGFRA mutations in GIST: A to Z” by Dr. Heinrich.

By |2018-05-29T13:29:32-04:00May 11th, 2007|Mutational Testing, Mutations|

Recent Posts

Upcoming Events

  1. SPAEN hosts webcast by Dr. Trent

    Novel Treatments in GIST

    July 24 @ 2:00 PM
  2. LRG Webcast Series: When to Consider Surgery

    August 8 @ 2:00 PM - 3:00 PM
  3. GDOL Ottawa logo

    GIST Day of Learning – Ottawa

    September 28 @ 9:00 AM - 4:30 PM