The Magic of Clinical Trial Math
How to Make 2/3 = 1 (100%) In a recent discussion about the frequency of mutations in GIST, we noted that the most common mutation is KIT exon 11, which makes up about 2/3 [...]
Life Fest 2018: Role of Mutational Analysis and Next Generation Sequencing in GIST
Role of Mutational Analysis and Next Generation Sequencing in GIST Andrew Rosenberg, MD, Sylvester Comprehensive Cancer Center View all Life Fest 2018 Videos
Mutational Testing and Genetics
So, I’ve been told that I have GIST! Life changes suddenly and profoundly when you receive a cancer diagnosis. It’s normal to experience a state of shock, but there is a practical need to [...]
New Technology Developed Which Can Predict GIST Patient’s Response to Drugs with Amazing Accuracy
Researchers have developed a test that can accurately identify over 20% of GIST patients that are unlikely to respond to currently approved treatments. In addition, it can identify which patients need a higher dose [...]
Informative Webcast Sheds Light on Mutational Analysis
Dr. Chris Corless In August, the LRG Webcast Series presented “Mutational Analysis of GISTs: How, When and Why.” Dr. Christopher Corless of Oregon Health and Science University (OHSU) presented the hour- long [...]
New Blood Testing Technology May Be Effective in Detecting Mutations
A new blood testing technology may lead to major changes in treatment of Gastrointestinal Stromal Tumors. In a study presented in April by Dr. George Demetri of the Dana-Farber Cancer Institute at the American Association for Cancer Research annual meeting, the blood test was shown to be more effective than traditional biopsies in identifying secondary mutations in GIST.
Personalized Medicine – Another Look
The issue of personalized medicine, also referred to as "precision medicine" in the article, was addressed in a newsletter article by LRG Executive Director Norman Scherzer in February. We hope to follow up with more articles on the topic soon.
Personalized medicine: is it myth or reality?
Executive Director’s report focuses on better treatment options for GISTers For my Executive Director’s report, I usually highlight the many accomplishments of the Life Raft Group. Some of which include: Launching a GIST Day [...]
New gene panel takes mutation testing to a new level
A new gene panel takes mutation testing to a new level. The panel tests for mutations in 23 genes at once will help to properly classify wild-type GIST patients. Working with next generation sequencing [...]
Mutational and Plasma Testing 101
Mutational testing determines whether you have a mutation present in your tumor, and what genotype it is. Examples include Exon 11 or 9 (for KIT positive tumors), Platelet Driven Growth Factor Receptor Alpha (PDGFRA), or [...]