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1 02, 2011

D842V Gets Its Moment in the Spotlight

By |2018-06-12T11:11:01-05:00February 1st, 2011|D842V, News, Patient Registry|

The Gleevec for GIST story continues to remain one of the most successful stories in oncology. What could be better than a drug that works in 85 percent of patients? As great as this story is, there is room for improvement. Half of the patients on Gleevec for metastatic disease will progress in the first two years and 15 percent of patients are resistant to Gleevec right away or within the first six months of treatment. AROG Pharmaceuticals may have an option for a few of those patients.

6 01, 2011

New Treatments of D842V Mutations

By |2019-04-03T12:02:19-05:00January 6th, 2011|Clinical Trials, D842V, Diagnosis, Mutational Testing, Mutations, News, Research|

 UPDATE - January 6th, 2011 by Jerry Call, LRG Science Coordinator The first ever clinical trial specifically for the PDGFRA D842V mutation has been announced by Arog pharmaceuticals. The phase II trial is scheduled [...]

20 12, 2007

References – PDGFRA and D842V

By |2019-08-26T14:48:37-05:00December 20th, 2007|D842V, Mutations, Research|

1. Agaram NP, Besmer P, Wong GC, Guo T, Socci ND, Maki RG, DeSantis D, Brennan MF, Singer S, DeMatteo RP, Antonescu CR: Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors. [...]

7 08, 2019

Blueprint Medicines Announces Next Step for Avaprinitib

By |2019-08-07T13:24:21-05:00August 7th, 2019|Drug Treatment, News|

Blueprint Medicines Announces FDA Acceptance of New Drug Application for Avapritinib for the Treatment of PDGFRA Exon 18 Mutant GIST and Fourth-Line GIST Blueprint Medicines announced today that the FDA and the EMA have [...]

20 06, 2019

New Horizons – International Focus on the Power of Real World Data to Enhance Advocacy Efforts

By |2019-08-26T16:17:01-05:00June 20th, 2019|Advocacy, Global, News, Newsletter|

New Horizons 2019 Meeting Gathers Advocates in NJ Not many of our readers know that The Life Raft Group has been involved with a global network of advocates since its inception. Every year country [...]

17 12, 2018

An Exciting Time for GIST Research

By |2019-01-02T14:49:47-05:00December 17th, 2018|Conferences, Newsletter, Research|

Left to right: Laura Occhiuzzi, Pete Knox, Alyssa O’Driscoll, Sarcoma Alliance, Annie Achee, National LeioMyoSarcoma Foundation, Denise Reinke, SARC, and Mitch Achee, National LeioMyoSarcoma Foundation. GIST Research from CTOS 2018 A web-based [...]

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